Surgically Induced Neuropathic Pain
نویسندگان
چکیده
منابع مشابه
Chemotherapy induced peripheral neuropathic pain
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most serious complications associated with anticancer drugs. CIPN leads to a lower quality of life and dysfunction of the sensory, motor, and autonomic systems, and often causes patients to discontinue chemotherapy. It is usually misdiagnosed and undertreated due to a lack of consensus and unclear pathophysiology, for which many me...
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Abstract Neuropathic pain induced by chemotherapy drugs such as oxaliplatin is a dose-limiting side effect in cancer treatment. The mechanisms underlying chemotherapy-induced neuropathic pain are not fully understood. KCNQ2 channels are low-threshold voltage-gated K+ channels that play a role in controlling neuronal excitability. Downregulation of KCNQ2 channels has been proposed to be an under...
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Despite the limited efficacy of current medical treatments, and the fact that they only treat the pain component of chemotherapy-induced peripheral neuropathy (CIPN), until recently there has been little interest in exploring surgical therapies for this condition. This is not at all surprising, because at first blush, it would seem that there is no rationale for a surgical approach to a systemi...
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Neuropathic pain is often the most distressing type of pain that can be suffered by any human being. In the clinical context of cancer, both detection and appropriate management lead not only to improved quality of life but also enables the patient to receive appropriate oncological management. The clinician needs to be aware of the complex pathophysiology of neuropathic pain which necessitates...
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Neuropathic pain results from damage to, or dysfunction of, the system that normally signals pain. The International Association for the Study of Pain (IASP 2007) defines neuropathic pain as follows: ‘Pain initiated or caused by a primary lesion or dysfunction in the nervous system. Peripheral neuropathic pain occurs when the lesion or dysfunction affects the peripheral nervous system. Central ...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 2013
ISSN: 0003-4932
DOI: 10.1097/sla.0b013e3182701a7b